2nd Macau Symposium on Biomedical Sciences 2015

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Status	已發表Published
	2nd Macau Symposium on Biomedical Sciences 2015
	Tan, K.; Rai, N.; Parsania, C.; Wong, M.L.; Wong, K. H.
	2015-07-10
Source Publication	2nd Macau Symposium on Biomedical Sciences 2015
Publication Place	Macau
Abstract	Protein kinases are central regulators of almost all cellular processes, which accounts for 1.5-2.5% of the eukaryote genomes. Mis-regulation of kinases can lead to adverse effects. 30% of human kinases are implicated in various diseases; hence, kinases are targets of many therapies. In silico analysis of kinase orthologues reveals that fungi share a large set of common kinases. A collection of deletion mutants for ninety-nine non-essential kinases is available for Aspergilus nidulans, a well-established research model for filamentous fungi. A. nidulans belongs to the Ascomycete lineage, which includes many species with important medical, industrial, agricultural and ecological significance. As kinases are central players for most cellular activities, kinase functions must play critical roles in survival of saprophytic fungi in the wild, in efficient productions of antibiotics, secondary metabolites, enzymes, food, etc. by industrial fungi as well as in virulence of human and plant fungal pathogens. In this study, we aim to apply a systematic and affordable transcription profiling strategy on the kinase mutant collection to map the physiological roles of individual kinases in order to gain a global understanding of the kinome in this model fungus. As kinase functions are often highly conserved, we reason that our findings will also provide valuable information to understanding the kinome of other medically, industrially and agriculturally important fungi.
Keyword	Systematic whole-genome transcription profiling analysis
Language	英語English
The Source to Article	PB_Publication
PUB ID	14771
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Wong, K. H.
Recommended Citation GB/T 7714	Tan, K.,Rai, N.,Parsania, C.,et al. 2nd Macau Symposium on Biomedical Sciences 2015[C], Macau, 2015.
APA	Tan, K.., Rai, N.., Parsania, C.., Wong, M.L.., & Wong, K. H. (2015). 2nd Macau Symposium on Biomedical Sciences 2015. 2nd Macau Symposium on Biomedical Sciences 2015.

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