Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response

doi:10.1021/acs.inorgchem.8b02256

UM > Institute of Chinese Medical Sciences

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	Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response
	Kang, Tian-Shu 1; Ko, Chung-Nga 2; Zhang, Jia-Tong 1; Wu, Chun 2; Wong, Chun-Yuen ; Ma, Dik-Lung 2; Leung, Chung-Hang1,3
	2018-11-19
Source Publication	INORGANIC CHEMISTRY
ISSN	0020-1669
Volume	57 Issue:22 Pages:14023-14026
Abstract	We describe in this study a rhodium(III) complex 1 as a new JMJD3 inhibitor and proinflammatory mediator. Complex 1 selectively inhibited the demethylation of H3K27me3 over other similar substrates, indicating its selectivity for JMJD3 over other histone demethylases, including JMJD2D and KDM5A. In terms of mechanism, complex 1 inhibited the JMJD3-H3K27me3 interaction in mouse macrophage cells and down-regulated the expression of TNF-alpha. To our knowledge, complex 1 is the first metal-based inhibitor of JMJD3 activity and only the second class of JMJD3 inhibitor reported overall.
DOI	10.1021/acs.inorgchem.8b02256
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Chemistry
WOS Subject	Chemistry, Inorganic & Nuclear
WOS ID	WOS:000451244700003
Publisher	AMER CHEMICAL SOC
Scopus ID	2-s2.0-85056174663
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 519020, Peoples R China; 2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong 518000, Hong Kong, Peoples R China; 3.City Univ Hong Kong, Dept Chem, Tat Chee Ave, Hong Kong 518000, Hong Kong, Peoples R China
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Kang, Tian-Shu,Ko, Chung-Nga,Zhang, Jia-Tong,et al. Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response[J]. INORGANIC CHEMISTRY, 2018, 57(22), 14023-14026.
APA	Kang, Tian-Shu., Ko, Chung-Nga., Zhang, Jia-Tong., Wu, Chun., Wong, Chun-Yuen., Ma, Dik-Lung., & Leung, Chung-Hang (2018). Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response. INORGANIC CHEMISTRY, 57(22), 14023-14026.
MLA	Kang, Tian-Shu,et al."Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response".INORGANIC CHEMISTRY 57.22(2018):14023-14026.

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