| Status | 已發表Published |
| Genomics analysis of non-essential protein kinases. | |
Tan, K.; Dong, Z.; Shirgaonkar, N.; Wong, K. H.
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| 2018-06-11 | |
| Source Publication | DNA Metabolism, Genomic Stability & Human Disease
 |
| Publication Place | Suzhou |
| Abstract | Protein kinases accounts for 1.5-2.5% of the eukaryote genomes and are major regulators of diverse cellular processes through reversible phosphorylation of protein targets. To better understand the kinome of the medically and industrially important research model fungus Aspergillus nidulans, we performed transcription profiling on 99 non-essential kinases deletion mutants in order to understand the global roles of individual kinases including those that have unknown function. Preliminary results of over 50 kinase mutants reveal many expected as well as unexpected functions of different kinases. The overall result will be valuable for identifying transcription factor and gene targets of kinases and also help to understand physiological functions of different kinases not only in this important fungal species but also in other fungal pathogens as well as higher eukaryotes. |
| Keyword | kinase Aspergillus Fungus |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 37704 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Tan, K.,Dong, Z.,Shirgaonkar, N.,et al. Genomics analysis of non-essential protein kinases.[C], Suzhou, 2018. |
| APA | Tan, K.., Dong, Z.., Shirgaonkar, N.., & Wong, K. H. (2018). Genomics analysis of non-essential protein kinases.. DNA Metabolism, Genomic Stability & Human Disease. |
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