Transcriptional dynamics during interactions of human fungal pathogens with macrophages.

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Status	已發表Published
	Transcriptional dynamics during interactions of human fungal pathogens with macrophages.
	Rai, N.; Wang, F.; Parsania, C.; Sethiya, P.; Tan, K.; Wong, K. H.
	2018-05-15
Source Publication	Regulatory & Non-Coding RNAs
Abstract	Pathogenic fungi have evolved diverse mechanisms to survive host immune responses. Studies aimed at dissecting the interactions between fungal pathogens and host phagocytes have revealed a number of fungal responses important for virulence. However, most studies focused on a later time point of infection and are often limited in temporal resolution. Consequently, the immediate and temporal responses of fungal pathogens upon phagocytosis are still not well defined. Moreover, a systematic comparison of responses among different fungal pathogens to understand common and unique responses has not been studied previously. In this work, we set out to map active transcription changes of several human fungal pathogens during macrophage infection. Our genome-wide data reveals the key physiological processes elicited by the pathogens during infection. Preliminary cross-species comparisons identified several conserved and diverse physiological responses employed by different fungal pathogens. In addition, we have also identified putative transcription regulators responsible for regulating the responses and are in the process of confirming their roles in the regulation as well as in virulence.
Keyword	human pathogen transcription macrophages
Language	英語English
The Source to Article	PB_Publication
PUB ID	39964
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Wong, K. H.
Recommended Citation GB/T 7714	Rai, N.,Wang, F.,Parsania, C.,et al. Transcriptional dynamics during interactions of human fungal pathogens with macrophages.[C], 2018.
APA	Rai, N.., Wang, F.., Parsania, C.., Sethiya, P.., Tan, K.., & Wong, K. H. (2018). Transcriptional dynamics during interactions of human fungal pathogens with macrophages.. Regulatory & Non-Coding RNAs.

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