| Status | 已發表Published |
| Anti-tussive alkaloids from roots of Stemona tuberosa | |
Lin, L. ; Li, K.; Tang, C.; Ke, C.; Rudd, J.; Lin, G.; Ye, Y.
| |
| 2008-05-02 | |
| Source Publication | Journal of Natural Products
 |
| ISSN | 0163-3864 |
| Pages | 1107-1110 |
| Abstract | Investigation of the roots of Stemona tuberosa afforded five minor constituents, stemoenonine (1), 9a-O-methylstemoenonine (2), oxystemoenonine (3), 1,9a-seco-stemoenonine (4), and oxystemoninine (5), along with the known compound stemoninoamide (6). Their structures were elucidated by 1D and 2D NMR spectra and other spectroscopic studies. Alkaloids 1, 2, and 6, as well as the representative stemoninine-type alkaloid, stemoninine (7), were screened for antitussive activity in the citric acid-induced guinea pig cough model. Compounds 6 and 7 exhibited strong antitussive activity after oral and intraperitoneal administrations. |
| Keyword | Stemona tuberosa alkaloids anti-tussive activity NMR |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 36233 |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Ye, Y. |
| Recommended Citation GB/T 7714 | Lin, L.,Li, K.,Tang, C.,et al. Anti-tussive alkaloids from roots of Stemona tuberosa[J]. Journal of Natural Products, 2008, 1107-1110. |
| APA | Lin, L.., Li, K.., Tang, C.., Ke, C.., Rudd, J.., Lin, G.., & Ye, Y. (2008). Anti-tussive alkaloids from roots of Stemona tuberosa. Journal of Natural Products, 1107-1110. |
| MLA | Lin, L.,et al."Anti-tussive alkaloids from roots of Stemona tuberosa".Journal of Natural Products (2008):1107-1110. |
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