A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging

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	A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging
	Zhang, J; Chen, HB; ZHou, T; Wang, LM; Gao, DY; Zhang, X.; Liu, YB; Wu, CF; Yuan, Z.
	2016-09-15
Source Publication	Nano Research
ISSN	1998-0000
Pages	1-14
Abstract	As a hybrid imaging technique, photoacoustic imaging (PAI) can provide multiscale morphological information of tissues and can recover the spatial distribution of interesting chromophores such as hemoglobin within tissues using multi-spectral PAI (MSPAI). Herein, we develop a contrast agent that can high-effectively combine multiscale PAI with MSPAI for a more comprehensive characterization of a complex biological tissues. In this study, we developed a novel PIID-DTBT based semiconducting polymer dots (Pdots) that have broad and strong optical absorption in the visible-light region (500 nm - 700 nm). Gold nanoparticles (GNPs) and gold nanorods (GNRs) that have been verified as an excellent PA contrast agent were compared with Pdots based on the multiscale PAI system. Both ex vivo and in vivo experiment demonstrated Pdots have a better PA conversion efficiency at 532 nm than GNPs and similar PA performance with GNRs at 700 nm at the same mass concentration. Photostability tests and toxicity tests demonstrated Pdots are photostable and biocompatible. More importantly, in vivo MSPAI experiment indicated Pdots have great PA performance than the blood and can be accurately extracted from the background of vascular-rich tissues. Our work demonstrates the great potential of Pdots as a highly effective contrast agent for precise localization of lesions relative to the blood vessels based on multiscale PAI and MSPAI.
Keyword	Nanoprobes photoacoustic imaging multiscale imaging multispectral imaging
Language	英語English
The Source to Article	PB_Publication
PUB ID	24863
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Yuan, Z.
Recommended Citation GB/T 7714	Zhang, J,Chen, HB,ZHou, T,et al. A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging[J]. Nano Research, 2016, 1-14.
APA	Zhang, J., Chen, HB., ZHou, T., Wang, LM., Gao, DY., Zhang, X.., Liu, YB., Wu, CF., & Yuan, Z. (2016). A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging. Nano Research, 1-14.
MLA	Zhang, J,et al."A PIID-DTBT based semiconducting polymer dot with broad and strong optical absorption in the visible-light region as a highly-effective contrast agent for multiscale and multi-spectral photoacoustic imaging".Nano Research (2016):1-14.

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