Water-soluble small-molecular probes for RNA based on two-photon fluorescence “off-on” process: Systematic analysis on live cell imaging and understanding on structure-activity relationships

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Water-soluble small-molecular probes for RNA based on two-photon fluorescence “off-on” process: Systematic analysis on live cell imaging and understanding on structure-activity relationships
	Li, H; Li, Y; Zhang, H; Xu, G; Zhang, Y; Liu, X; Zhou, H; Yang, X; Tian, Y; Zhang, X.
	2017-11-17
Source Publication	Chemical Communications
ISSN	1359-7345
Pages	13245-13248
Abstract	The conveniently obtained water-soluble small-molecule L1–5 were selective for RNA with remarkable ‘‘off–on’’ two-photon fluorescence responses in vitro and in vivo, showing that L1–5 can surprisingly stain mitochondria or nucleoli individually with orange fluorescence under different focal lengths. Compounds L6–8 were prepared, for comparison, to further explore the mechanism of the binding of L1–5 with RNA, which revealed that the synergistic effect of the amino group and the pyridinium cation played a significant role in distinct cell imaging
Keyword	RNA probe two-photon structure-activity relationships
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	36338
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Recommended Citation GB/T 7714	Li, H,Li, Y,Zhang, H,et al. Water-soluble small-molecular probes for RNA based on two-photon fluorescence “off-on” process: Systematic analysis on live cell imaging and understanding on structure-activity relationships[J]. Chemical Communications, 2017, 13245-13248.
APA	Li, H., Li, Y., Zhang, H., Xu, G., Zhang, Y., Liu, X., Zhou, H., Yang, X., Tian, Y., & Zhang, X. (2017). Water-soluble small-molecular probes for RNA based on two-photon fluorescence “off-on” process: Systematic analysis on live cell imaging and understanding on structure-activity relationships. Chemical Communications, 13245-13248.
MLA	Li, H,et al."Water-soluble small-molecular probes for RNA based on two-photon fluorescence “off-on” process: Systematic analysis on live cell imaging and understanding on structure-activity relationships".Chemical Communications (2017):13245-13248.

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