The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases
	Kou, M. T.; Chong, C. M.; Ai, N.; Lee, M. Y.
	2016-05-01
Source Publication	Progress in Modern Biomedicine
ISSN	1673-6273
Pages	2780-2782
Abstract	ROCK, also called Rho associated coiled coil protein kinase, is a serine / threonine protein kinase. And it is a downstream substrate of small G protein Rho. ROCK is known to involve in the function of neurons. More and more sudies showed that ROCK inhibition have the dominant effects on various experimental models of neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Thus, ROCK becomes the potential drug target for neurodegeneration-related diseases. The application and development of ROCK inhibitors for neurodegenerative diseases was summarized in this article with the purpose to increase the level of he therapies and application of neurodegenerative diseases.
Keyword	ROCK Rho Neurodegenerative diseases ROCK inhibitor
Language	其他語言Others
The Source to Article	PB_Publication
PUB ID	57845
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Lee, M. Y.
Recommended Citation GB/T 7714	Kou, M. T.,Chong, C. M.,Ai, N.,et al. The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases[J]. Progress in Modern Biomedicine, 2016, 2780-2782.
APA	Kou, M. T.., Chong, C. M.., Ai, N.., & Lee, M. Y. (2016). The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases. Progress in Modern Biomedicine, 2780-2782.
MLA	Kou, M. T.,et al."The application of Rho-associated protein kinase (ROCK) inhibitors in neurodegenerative diseases".Progress in Modern Biomedicine (2016):2780-2782.

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