A vesicle-intrinsically regulated pathway for apical polarity

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	A vesicle-intrinsically regulated pathway for apical polarity
	Zhang, N.; Zhang, H.; Khan, L.; Gholamali , G.; Eun, Y.; Membreno, E.; El-Daouk, R.; Gobel, V.
	2016-07-01
Source Publication	The Allied Genetics Conference 2016 Full Abstract book
Abstract	Polarized epithelial membrane domains are thought to be established by membrane- and junction-associated polarity cues (e.g. partitioning defective PARs), with directional trafficking subsequently maintaining them. Our prior work showed that glycosphingolipids (GSLs), clathrin and its AP-1 adaptor function as vesicle-associated apical polarity cues in C. elegans tubular epithelia. Their loss causes intestinal polarity inversion with a full basolateral-to-apical membrane domain conversion and ectopic lateral lumen formation. These and other findings suggested that trafficking itself may define polarized domain identities, in part by targeting polarity determinants (e.g. PARs), but possibly by targeting multiple membrane components. Here, the GSL-loss-of-function intestinal polarity inversion phenotype was used to identify components and map trajectories of such a putative vesicle-intrinsically regulated apical polarity pathway. We mined three of our unbiased and targeted multi- and unicellular tubulogenesis screens that had examined the asymmetrical placement and function of the apical/lumenal actin linker ERM-1 for genes with predicted roles in trafficking. 49 trafficking genes with a broad range of vesicle-associated functions were identified as required for apical membrane biog
Keyword	Vesicle apical polarity
Language	英語English
The Source to Article	PB_Publication
PUB ID	21277
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Gobel, V.
Recommended Citation GB/T 7714	Zhang, N.,Zhang, H.,Khan, L.,et al. A vesicle-intrinsically regulated pathway for apical polarity[C], 2016.
APA	Zhang, N.., Zhang, H.., Khan, L.., Gholamali , G.., Eun, Y.., Membreno, E.., El-Daouk, R.., & Gobel, V. (2016). A vesicle-intrinsically regulated pathway for apical polarity. The Allied Genetics Conference 2016 Full Abstract book.

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