Degradation for better survival? Role of ubiquitination in epithelial morphogenesis

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Status	已發表Published
	Degradation for better survival? Role of ubiquitination in epithelial morphogenesis
	Cheng, X.; Zhang, H.
	2018-08-01
Source Publication	The 5th Chinese C. elegans Meeting Abstract Book
Abstract	As a prevalent post-translational modification, ubiquitination is essential for many developmental processes. Once covalently attached to the small and conserved polypeptide ubiquitin (Ub), a substrate protein can be directed to perform specific biological functions via its Ub-modified form. Three sequential catalytic reactions contribute to this process, among which E3 ligases serve to identify target substrates and promote the activated Ub to conjugate to substrate proteins. Ubiquitination has great plasticity, with diverse numbers, topologies and modifications of Ub chains conjugated at different substrate residues adding a layer of complexity that facilitates a huge range of cellular functions. Herein, we highlight key advances in the understanding of ubiquitination in epithelial morphogenesis, with an emphasis on the latest insights into its roles in cellular events involved in polarized epithelial tissue, including cell adhesion, asymmetric localization of polarity determinants and cytoskeletal organization. In addition, the physiological roles of ubiquitination are discussed for typical examples of epithelial morphogenesis, such as lung branching, vascular development and synaptic formation and plasticity. Our increased understanding of ubiquitination in epithelial morphogenesis may provide novel insights into the molecular mechanisms underlying epithelial regeneration and maintenance.
Keyword	Ubiquitination epithelial morphogenesis
Language	英語English
The Source to Article	PB_Publication
PUB ID	46771
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Zhang, H.
Recommended Citation GB/T 7714	Cheng, X.,Zhang, H.. Degradation for better survival? Role of ubiquitination in epithelial morphogenesis[C], 2018.
APA	Cheng, X.., & Zhang, H. (2018). Degradation for better survival? Role of ubiquitination in epithelial morphogenesis. The 5th Chinese C. elegans Meeting Abstract Book.

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