| Status | 已發表Published |
| To be a medicine or a toxin? This is a question – a sphingolipid story | |
Zhang, H.
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| 2017-10-14 | |
| Source Publication | Clinical Pharmacology and Toxicology Research
 |
| ISSN | 0000-0000 |
| Pages | 8-8 |
| Abstract | From being a medicine to being a toxin there is a step. This is true for many aspects: from the structure, to the effect and to the dosage. For example, myriocin (ISP-1), a potent immunosuppressant, is an analog of sphingosine, and also an inhibitor of the enzyme serine palmitoyltransferase that generates sphingosine. However, when it comes to the physiological effect, myriocin inhibits the growth of a mouse cytotoxic T lymphocyte line whereas sphingosine completely suppresses the inhibitory effect. But while you may think sphingosine is “good”, and that more is better, high doses of sphingosine actually start inhibiting protein kinase C activity, therefore also causing growth arrest. So, from sphingosine being a “medicine” to restore growth to being a “toxin” to inhibit growth, it only needs either a minor structural modification to become myriocin, or an increase in its own concentration. |
| Keyword | Medicine toxin sphingolipid |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 37887 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | Zhang, H. |
| Recommended Citation GB/T 7714 | Zhang, H.. To be a medicine or a toxin? This is a question – a sphingolipid story[J]. Clinical Pharmacology and Toxicology Research, 2017, 8-8. |
| APA | Zhang, H..(2017). To be a medicine or a toxin? This is a question – a sphingolipid story. Clinical Pharmacology and Toxicology Research, 8-8. |
| MLA | Zhang, H.."To be a medicine or a toxin? This is a question – a sphingolipid story".Clinical Pharmacology and Toxicology Research (2017):8-8. |
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