Interactome an alysis to Study the Molecular Mechanism of Heparin‐induced Cardiomyocyte Differentiation.

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	Interactome an alysis to Study the Molecular Mechanism of Heparin‐induced Cardiomyocyte Differentiation.
	Chen, G.; Ren, Z.; Meng, Y.; Liu, W.
	2019-12-07
Source Publication	ASCB/EMBO 2019 Meeting Abstracts: Poster Presentations
Abstract	Human embryonic stem cells (hESCs) are a powerful model to understand the molecular mechanisms involved in human embryogenesis. Heparin and albumin are common cell culture components, and they are widely used in various cell type‐specific differentiation from hESCs. However, their molecular mechanisms in differentiation are often unclear, because it is difficult to identify the functional target among their numerous binding partners. Both heparin and albumin positively promote cardiomyocyte differentiation, and heparin can even generate cardiomyocytes in the absence of WNT inhibitors. Through interactome analysis, we identified a set of binding or functional partners shared by albumin and heparin from hundreds of candidates. Further analysis identified novel target proteins involved in cardiomyocyte determination. This study highlights interactome analysis as an effective method to study the molecular mechanisms of complicated proteins, and we also revealed new mechanisms involved in cardiomyocyte differentiation.
Keyword	hESC Cardiomyocyte Heparin Albumin Interactome
Language	英語English
The Source to Article	PB_Publication
PUB ID	49624
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Chen, G.
Recommended Citation GB/T 7714	Chen, G.,Ren, Z.,Meng, Y.,et al. Interactome an alysis to Study the Molecular Mechanism of Heparin‐induced Cardiomyocyte Differentiation.[C], 2019.
APA	Chen, G.., Ren, Z.., Meng, Y.., & Liu, W. (2019). Interactome an alysis to Study the Molecular Mechanism of Heparin‐induced Cardiomyocyte Differentiation.. ASCB/EMBO 2019 Meeting Abstracts: Poster Presentations.

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