| Residential College | true |
| Status | 已發表Published |
| Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles | |
Zhou, LD ; Chen, FQ; Bao, JL; Wang, SP; Wang, L; Chen, MW ; He, C. W. ; Wang, Y. T.
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| 2016-03-23 | |
| Source Publication | Drug Delivery
 |
| ISSN | 1071-7544 |
| Pages | 898-906 |
| Abstract | Evodiamine (EVO) is a plant-derived indolequinazoline alkaloid with potential anticancer activity. However, low bioavailability caused by its poor water solubility limits it anticancer efficacy in clinic. To enhance the solubility and improve the bioavailability of EVO, a delivery system based on poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with EVO (EVO-PLGA NPs) for treating breast cancer was prepared in this study. The physicochemical characterization andin vitro antitumor evaluation of EVO-PLGA NPs were determined. EVO-PLGA NPs could persistently control the release of EVO for 180 h. 3-[4,5-Dimethyl-2-thiazolyl]-2,5-diphenyl tetrazolium bromide (MTT) assessment and colony formation assay showed that EVO-PLGA NPs could enhance the toxicity and the proliferation inhibition effect of EVO on MCF-7 breast cancer cells. EVO-PLGA NPs did not strengthen G2/M arrest effect of EVO-treated cells after 24h incubation. Meanwhile, EVO-PLGA NPs could increase the expression of cyclin B1 and decrease the expression ofb-actin. Taken together, these results suggested that -PLGA NPs is promising for improving anticancer efficacy of EVO in breast cancer therapy. |
| Keyword | Anticancer Activity Plga Nanoparticles Breast Cancer Evodiamine Formulation |
| DOI | 10.3109/10717544.2014.920936 |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Chen, MW; He, C. W. |
| Affiliation | University of Macau |
| First Author Affilication | University of Macau |
| Corresponding Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Zhou, LD,Chen, FQ,Bao, JL,et al. Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles[J]. Drug Delivery, 2016, 898-906. |
| APA | Zhou, LD., Chen, FQ., Bao, JL., Wang, SP., Wang, L., Chen, MW., He, C. W.., & Wang, Y. T. (2016). Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles. Drug Delivery, 898-906. |
| MLA | Zhou, LD,et al."Preparation, Characterization, and Antitumor Efficacy of Evodiamine Loaded PLGA Nanoparticles".Drug Delivery (2016):898-906. |
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