Triptolide-loaded microemulsion hydrogel overcome psoriatic skin barrier with deeper but fewer drug penetration through skin appendages

UM > Faculty of Health Sciences > DEPARTMENT OF PHARMACEUTICAL SCIENCES

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	Triptolide-loaded microemulsion hydrogel overcome psoriatic skin barrier with deeper but fewer drug penetration through skin appendages
	Liu, Z.; Sun, L.; Wang, L.; Cun, D.; Tong, H.; Chen, X.; Wang, R.; Zheng, Y.
	2016-11-18
Source Publication	The2nd Academic Annual Meeting of the Specialty Committee of Transdermal Drug Delivery of World Federation of Chinese Medicine Societies
Abstract	The average diameter of ME was 31.04±0.15 nm. For in vitro transdermal permeation studies, the cumulative permeated amount of TP was presented in Figure 1. As for percutaneous rate, 5.00±0.10 μg/cm2/h of TP GEL and 3.07±0.04 μg/cm2/h of TP ME GEL were for pathological skin, while 3.43±0.18 μg/cm2/h of TP GEL and 2.81±0.14 μg/cm2/h of TP ME GEL were for normal skin in 48h. Compared to TP GEL, TP ME GEL penetrated less in both psoriatic skin and normal skin. As shown in Figure 2, NR GEL penetrated in a way of layer by layer while NR in ME GEL mainly accumulated in the skin appendages and afterwards released from the base of the hair follicles into the deep of the dermis. Therefore, using these appendages, for instance the hair follicles and sweat glands, as channels helps ME go through stratum corneum layer and arrive at the bottom of dermis easily. Meanwhile, due to the limited area and volume of the appendages, the delivered amount of TP ME GEL in skin is less than TP GEL which becomes a natural controller for the concentration of toxic drugs.
Keyword	Microemulsion Hydrogel Psoriatic Skin Barrier
Language	英語English
The Source to Article	PB_Publication
PUB ID	33433
Document Type	Conference paper
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding Author	Zheng, Y.
Recommended Citation GB/T 7714	Liu, Z.,Sun, L.,Wang, L.,et al. Triptolide-loaded microemulsion hydrogel overcome psoriatic skin barrier with deeper but fewer drug penetration through skin appendages[C], 2016.
APA	Liu, Z.., Sun, L.., Wang, L.., Cun, D.., Tong, H.., Chen, X.., Wang, R.., & Zheng, Y. (2016). Triptolide-loaded microemulsion hydrogel overcome psoriatic skin barrier with deeper but fewer drug penetration through skin appendages. The2nd Academic Annual Meeting of the Specialty Committee of Transdermal Drug Delivery of World Federation of Chinese Medicine Societies.

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