| Status | 已發表Published |
| Cucurbit[7]uril as a Specific Antidote for Paraquat Poisoning | |
Zhang, X. ; Wang, R. 
| |
| 2018-07-08 | |
| Source Publication | Proceedings for International Symposium on Macrocyclic and Supramolecular Chemistry
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| Abstract | Accidental or intentional ingestion of paraquat (PQ) may result in higherthan-60% fatality worldwide, without effective antidotes available. We introduce a potential treatment paradigm for PQ poisoning, based on specific binding of PQ by a synthetic macrocyclic molecule, cucurbit[7]uril (CB[7]). CB[7] is a cyclic methylene-bridged glycoluril heptamer with the shape resembling that of a pumpkin. This molecule exhibited a high affinity with PQ in pH 1.2~7.4 buffers. In the presence of CB[7], cellular uptake of PQ was dramatically inhibited, and PQ induced generation of reactive oxygen species (ROS) and apoptosis in cellular models were both reduced and cellular viability was increased. In mouse model studies, when co-administered with CB[7], PQ levels in the plasma and major organs were significantly decreased. Meanwhile, PQ ingestion induced major organ injuries (including the intestine, lung, liver and kidney) , as well as the unusual blood counts, were also significantly alleviated. Survival studies indicated that oral administration of CB[7] within 2 hours post PQ ingestion may significantly increase the survival rates of the mice. Taken together, CB[7] is a potential translational antidote for PQ poisoning by specifically binding PQ and inhibiting its absorption in gastrointestinal tracts. |
| Keyword | cucurbit[7]uril antidote |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 38610 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Zhang, X.,Wang, R.. Cucurbit[7]uril as a Specific Antidote for Paraquat Poisoning[C], 2018. |
| APA | Zhang, X.., & Wang, R. (2018). Cucurbit[7]uril as a Specific Antidote for Paraquat Poisoning. Proceedings for International Symposium on Macrocyclic and Supramolecular Chemistry. |
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