Supramolecular encapsulation of a halonium cation by cucurbit[n]uril (n = 7, 8): binding properties and effect of encapsulation on biological activities of the guest

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Supramolecular encapsulation of a halonium cation by cucurbit[n]uril (n = 7, 8): binding properties and effect of encapsulation on biological activities of the guest
	Yin, H.; Huang, Q.; Wang, R.
	2017-08-20
Source Publication	Proceedings for The 14th International Conference on Calixarenes (Calix2017)
Abstract	Here we report an unprecedented encapsulation of a halonium cation, diphenyleneiodonium (DPI), by cucurbit[n]uril (CB[n], n =,7 and 8). The DPI-CB[n] host-guest binging behaviors were investigated by 1H NMR, UV-visible spectroscopic titrations, isothermal titration calorimetry (ITC) titration, electrospray ionization (ESI) mass spectrometry, and density functional theory (DFT) molecular modeling. Upon encapsulation, DPI formed 1:1 host-guest complexes with CB[7] with a binding affinity Ka of (3.13 ~ 6.63) × 104 M-1 and 1:2 host-guest complexes with CB[8] with a binding affinity Ka of 2.26 × 1012 M-2 in aqueous solutions, respectively. Upon encapsulation by CB[7] and CB[8], the bioactivity of DPI in inhibiting ROS generation was moderately improved as shown by an in vitro model based on RAW 264.7 cell line, whereas the cardiac toxicity of DPI was decreased as evidenced by an in vitro test on H9c2 cell line and an in vivo test on zebrafish models. This study has demonstrated for the first time that CB[7] and CB[8] may function as potential pharmaceutical excipients to enhance the bioactivity and alleviate the cardiac toxicity of halonium based drug species such as DPI.
Keyword	supramolecular encapsulation halonium cation cucurbit[n]uril
Language	英語English
The Source to Article	PB_Publication
PUB ID	38597
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.
Recommended Citation GB/T 7714	Yin, H.,Huang, Q.,Wang, R.. Supramolecular encapsulation of a halonium cation by cucurbit[n]uril (n = 7, 8): binding properties and effect of encapsulation on biological activities of the guest[C], 2017.
APA	Yin, H.., Huang, Q.., & Wang, R. (2017). Supramolecular encapsulation of a halonium cation by cucurbit[n]uril (n = 7, 8): binding properties and effect of encapsulation on biological activities of the guest. Proceedings for The 14th International Conference on Calixarenes (Calix2017).

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh