Supramolecular Medicine based on Cucurbiturils

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Supramolecular Medicine based on Cucurbiturils
	Li, S.; Yang, X.; Yin, H.; Wang, R.
	2017-08-20
Source Publication	Proceedings for The 14th International Conference on Calixarenes (Calix2017)
Abstract	Cucurbit[n]urils (CB[n]), an emerging family of macrocyclic molecules, consist of n glycoluril units connected by 2n methylene groups, and they possess not only a hydrophobic internal cavity that can encapsulate various lipophilic guest molecules, but also the two carbonyl-fringed portals that are good cation-receptors. The chemical and biological activity of a guest molecule is often altered upon encapsulation by CB[n]. During the past several years, a number of reports (including ours) regarding the encapsulation of bioactive molecules have demonstrated that CB[n] encapsulation often leads to improved solubility, chemical stability, and therapeutic efficacy as well as reduced side-effects. Our research group has been actively investigating CB[n]’s biocompatibility and their complexations with a variety of drug molecules and biomedically important molecules during the past a couple of years, from both organic chemistry and pharmaceutical sciences perspectives. For instance, we have discovered that supramolecular encapsulation of a variety of drugs by CB[n] may help alleviate the toxic side-effects of these drugs, whereas their therapeutic efficacy is not compromised. We are also among the first to investigate CB[n]’s potential as a reversal agent for toxic reagents. In this presentation, we will discuss about our most recent research progress of these efforts.
Keyword	Supramolecular Medicine Cucurbiturils
Language	英語English
The Source to Article	PB_Publication
PUB ID	38606
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.
Recommended Citation GB/T 7714	Li, S.,Yang, X.,Yin, H.,et al. Supramolecular Medicine based on Cucurbiturils[C], 2017.
APA	Li, S.., Yang, X.., Yin, H.., & Wang, R. (2017). Supramolecular Medicine based on Cucurbiturils. Proceedings for The 14th International Conference on Calixarenes (Calix2017).

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