| Status | 已發表Published |
| The use of cucurbiturils in pharmaceutical sciences | |
Wang, R. 
| |
| 2016-08-28 | |
| Source Publication | The 10th National Symposium for Supramolecular Chemistry
 |
| Abstract | Cucurbit[n]urils (CB[n]), an emerging family of macrocyclic molecules, consist of n glycoluril units connected by 2n methylene groups, and they not only possess a hydrophobic internal cavity that can encapsulate guest molecules, but also the two carbonyl-fringed portals that are good cation-receptors. The chemical and biological activity of a guest molecule is often altered upon encapsulation by CB[n].[1] During the past decade, numerous reports regarding the encapsulation of bioactive molecules have demonstrated that CB[n] encapsulation often leads to improved solubility, chemical stability, and therapeutic efficacy as well as reduced side-effects.[2],[3] Our research group has been actively investigating CB[n]’s biocompatibility and its complexation with a variety of drug molecules and medically important molecules during the past several years, from both chemistry and biomedical sciences perspectives. In this presentation, we will discuss about our recent progress of these efforts. We intend to bring forward the use of CB[n]s as either functional excipients or as drugs potentially (Figure 1). |
| Keyword | excipient cucurbiturils pharmaceutics |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 28041 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. The use of cucurbiturils in pharmaceutical sciences[C], 2016. |
| APA | Wang, R..(2016). The use of cucurbiturils in pharmaceutical sciences. The 10th National Symposium for Supramolecular Chemistry. |
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