| Status | 已發表Published |
| Molecular Encapsulation of Phytochemicals by Cucurbit[7]urils | |
Yang, X. ; Li, S.; Yin, H.; Huang, Q.; Kuok, J.; Wang, R. 
| |
| 2017-07-01 | |
| Source Publication | 2nd ISPMF
 |
| Abstract | Cucurbit[n]urils (CB[n]), an emerging family of macrocyclic molecules, consist of n glycoluril units connected by 2n methylene groups, and they possess not only a hydrophobic internal cavity that can encapsulate various lipophilic guest molecules, but also the two carbonyl-fringed portals that are good cation-receptors. The chemical and biological activity of a guest molecule is often altered upon encapsulation by CB[n]. During the past several years, a number of reports (including ours) regarding the encapsulation of bioactive molecules including several important phytochemicals have demonstrated that CB[n] encapsulation often leads to improved solubility, chemical stability, and therapeutic efficacy as well as reduced side-effects. Our research group has been actively investigating CB[n]’s biocompatibility and its complexation with a variety of biomedically important phytochemicals during the past a couple of years, from both phytomedicine and pharmaceutical sciences perspectives. For instance, we have discovered that supramolecular encapsulation of several phytochemicals by CB[n] may help alleviate the toxic side-effects of these molecules, whereas their therapeutic efficacy is not compromised (in some cases, the therapeutic activities are even improved). We are also among the first to investigate CB[n]’s potential as a reversal agent for toxic phytochemicals and synthetic agents. In this presentation, we will discuss about our recent progress of these efforts. |
| Keyword | Phytochemicals Cucurbiturils |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 31831 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Yang, X.,Li, S.,Yin, H.,et al. Molecular Encapsulation of Phytochemicals by Cucurbit[7]urils[C], 2017. |
| APA | Yang, X.., Li, S.., Yin, H.., Huang, Q.., Kuok, J.., & Wang, R. (2017). Molecular Encapsulation of Phytochemicals by Cucurbit[7]urils. 2nd ISPMF. |
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