Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity with Preserved Anti-Cancer Activity

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity with Preserved Anti-Cancer Activity
	Wang, R.; Yang, X.; Li, S.; Yin, H.
	2016-07-01
Source Publication	23rd IUPAC Conference on Physical Organic Chemistry (ICPOC23)
Abstract	Cucurbit[n]urils (CB[n]s, n=5-8, 10, 14), an emerging family of macrocyclic molecules, have recently exhibited great potential as promising candidates for the next generation of medical excipients in pharmaceutical research.1 Among this family of molecules, CB[7] has attracted the most attention in biomedical sciences due to its superior water-solubility and well-understood biocompatibility.2 In this report, we will discuss about the use of CB[7] for molecular encapsulation and formulation of a natural anti-cancer agent, camptothecin (CPT). The associated benefits of such encapsulation of CPT on its anti-cancer activity and side effects have been systemically evaluated both in vitro and in vivo. The cytotoxicity of free CPT and CPT@CB[7] was firstly studied by MTT assay using both a healthy liver cell line (L02) and a liver cancer cell line (Bel-7420). Interestingly, free CPT and CPT@CB[7] demonstrated comparable anti-cancer efficacy in vitro on the cancer cell line Bel-7420, whereas CPT@CB[7] showed obviously lower toxicity on the healthy liver cell line L02, in comparison with the free CPT. The anti-cancer activity and its non-specific side-effects of both free CPT and CPT@CB[7] were further investigated in vivo with a transgenic zebrafish model, confirming that CPT@CB[7] exhib
Keyword	camptothecin cucurbituril encapsulation toxicity
Language	英語English
The Source to Article	PB_Publication
PUB ID	21163
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.
Recommended Citation GB/T 7714	Wang, R.,Yang, X.,Li, S.,et al. Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity with Preserved Anti-Cancer Activity[C], 2016.
APA	Wang, R.., Yang, X.., Li, S.., & Yin, H. (2016). Encapsulation of Camptothecin by Cucurbit[7]uril: Reduced Toxicity with Preserved Anti-Cancer Activity. 23rd IUPAC Conference on Physical Organic Chemistry (ICPOC23).

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