| Status | 已發表Published |
| Supramolecular Encapsulation of Alagebrium by Cucurbit[7]uril Inhibited the H/D Exchange of both its Carbonyl α-Hydrogen and Thiazolium C(2)-Hydrogen | |
Li, S. ; Wang, R. 
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| 2016-08-28 | |
| Source Publication | The 10th National Symposium for Supramolecular Chemistry
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| Abstract | Keto-enol tautomerism, which refers to the interconversion equilibrium between keto form and enol form, has drawn considerable interest due to its crucial role in both organic reaction and biological transformation. Moreover, the degradation of many biologically important molecules is often attributed to the labile carbonyl α-H. We have previously reported that the inclusion of imidazolium and thiazolium based model drugs by cucurbit[7]uril (CB[7]) may protect the labile C(2)-H and shift up their pKa values. Recently, for the first time we have observed CB[7]’s capability to inhibit the keto-enol tautomerism by using a model drug alagebrium, in addition to inhibition the already-known C(2)-H activity. |
| Keyword | Cucurbit[7]uril Alagebrium Keto-enol Tautomerism H/D exchange C(2)-Hydrogen |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 38961 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Li, S.,Wang, R.. Supramolecular Encapsulation of Alagebrium by Cucurbit[7]uril Inhibited the H/D Exchange of both its Carbonyl α-Hydrogen and Thiazolium C(2)-Hydrogen[C], 2016. |
| APA | Li, S.., & Wang, R. (2016). Supramolecular Encapsulation of Alagebrium by Cucurbit[7]uril Inhibited the H/D Exchange of both its Carbonyl α-Hydrogen and Thiazolium C(2)-Hydrogen. The 10th National Symposium for Supramolecular Chemistry. |
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