Supramolecular Interactions of Cucurbit[n]uril Homologues and Derivatives with Biomolecules and Drugs

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Supramolecular Interactions of Cucurbit[n]uril Homologues and Derivatives with Biomolecules and Drugs
	Cheng, Q.; Yin, H.; Wyman, I.; Wang, R.
	2019-09-04
Source Publication	Cucurbituril-based Functional Materials
Publisher	Royal Society of Chemistry
Pages	193-216
Abstract	The cucurbit[n]uril (CB[n]) family is an emerging class of host molecules in the field of supramolecular chemistry with a relatively short history (except for CB[6]). The internal cavities of CB[n]s are nonpolar and hydrophobic, guarded by two carbonyl-laced portals, thus they can encapsulate not only neutral molecules via hydrophobic effects but also complex cationic species via ion–dipole interactions. Due to these unique properties, many promising discoveries of supramolecular interactions between CB[n]s and biomolecules and small organic drug molecules have emerged with potential implications in the field of pharmaceutical sciences, which have become one of the most significant areas of potential applications for CB[n]s. In this chapter, we summarize the noncovalent interactions of peptides, proteins and drug molecules with CB[n] homologues and derivatives and discuss the ability of CB[n]s to modulate the functions and bioactivities of these species through host–guest chemistry, as well as the potential of CB[n]s for protein enrichments, together with other relevant topics.
Keyword	Host-guest drugs cucurbiturils formulations
Language	英語English
ISBN	9781788014885
The Source to Article	PB_Publication
PUB ID	49347
Document Type	Book chapter
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.
Recommended Citation GB/T 7714	Cheng, Q.,Yin, H.,Wyman, I.,et al. Supramolecular Interactions of Cucurbit[n]uril Homologues and Derivatives with Biomolecules and Drugs[M]. Cucurbituril-based Functional Materials:Royal Society of Chemistry, 2019, 193-216.
APA	Cheng, Q.., Yin, H.., Wyman, I.., & Wang, R. (2019). Supramolecular Interactions of Cucurbit[n]uril Homologues and Derivatives with Biomolecules and Drugs. Cucurbituril-based Functional Materials, 193-216.

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