Various drug delivery systems (DDSs) have been developed in recent years to address the systemic toxicity, poor cellular uptake and low therapeutic efficacy caused by conventional chemotherapy. Hyaluronic acid (HA), as a natural polysaccharide, has been frequently employed as a building block in pharmaceutics due to its excellent biocompatibility, biodegradability and tumor-targeting capability. However, complicated design and tedious synthesis are often involved for fabricating HA based DDSs which is time-consuming and may introduce safety issues. Moreover, imaging-guided multimodality cancer therapy based on HA has been rare.1 Herein, we report a metallic HA nanogels (HANGs) in which doxorubicin hydrochloride (DOX) and indocyanine green (ICG) were simultaneously entrapped in the matrix of HANGs to yield DOX/ICG loaded HANGs (ICGHANGs/DOX) (Scheme 1). 2 Histidine (His) was first grafted onto HA to form HA-His, and HANGs were readily fabricated subsequently via coordination and electrostatic interaction between HA-His and Mn2+. ICG and DOX could be readily loaded during the preparation process of HANGs. The sizes and morphology of ICGHANGs/DOX were fully characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). The ICGHANGs/DOX demonstrated superior stability in vitro, and the cargoes were released specifically in tumor cells in response to the local microenvironments including the low pH and/or high GSH. Furthermore, the presence of photothermal ICG and paramagnetic Mn2+of ICGHANGs/DOX allowed photoacoustic imaging (PA) and NMR imaging of in vitro and in vivo. The combination of chemotherapy and phototherapy have shown synergistic therapeutic effects with negligible systematic toxicity. Thus, this work provides a facile, yet novel, strategy to have multi-modality bioimaging and therapeuties in one platform to realize integrated theranostics with significant potential for improved cancer therapy.