| Status | 已發表Published |
| Nanomedicine with noncovalently tailorable surface for image-guided therapy | |
Wang, R. 
| |
| 2019-04-19 | |
| Source Publication | The 2nd International Symposium for Chinese Supramolecular Chemists
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| Abstract | Surface functionalization of nanoparticles (NPs) is of pivotal importance in nanomedicine. However, traditional strategies often require covalent conjugation that involves laborious design and synthesis for each specific medical need. A “toolbox” of surface ligands that can be used with “click and serve” approach for a variety of nanomedicines would be highly appreciated. Herein, cucurbit[7]uril (CB[7])-decorated polymeric and inorganic NPs were developed and exploited as stimuli-responsive drug delivery platforms for image-guided, targeted therapy.1 CB[7] on the surface of NPs allowed facile, modular surface modification with a variety of functional moieties or tags that are linked with amantadine (ADA, which is known to strongly bind with CB[7]), including ADA-conjugated folate (for targeted delivery), polyethylene glycol (for reducing immunogenicity) and fluorescein isothiocyanate (as a dye for optical imaging). In addition, surface CB[7] also allowed binding of a chemotherapeutic drug, oxaliplatin. As a proof-of-concept, we demonstrated that a variety of NPs (including PLGA, Gold, Fe3O4, and Nanocapulses) with modularly functionalized surface may specifically target cancer cells or tissues for image-guided, improved cancer therapy. These studies may offer new insights to the design and development of novel nanomedicines with modularly tailorable surface. |
| Keyword | Nanomedicine noncovalently tailorable surface image-guided therapy |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 44769 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. Nanomedicine with noncovalently tailorable surface for image-guided therapy[C], 2019. |
| APA | Wang, R..(2019). Nanomedicine with noncovalently tailorable surface for image-guided therapy. The 2nd International Symposium for Chinese Supramolecular Chemists. |
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