| Status | 已發表Published |
| Dual stimuli-responsive perallyloxycucurbit[6]uril-based nanoparticles for selective drug delivery in cancer cells | |
Wang, R. 
| |
| 2019-03-11 | |
| Source Publication | Sixth International Conference on Multifunctional, Hybrid and Nanomaterials
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| Abstract | Introduction: Herein we report novel, dual stimuli (light and GSH) responsive nanoparticles directly formed from perallyloxycucurbit[6]uril (AO12CB[6]) for specifically delivering chemotherapeutic drugs into cancer cells Methods: Firstly, emulsion method was employed to fabricate AO12CB[6] nanoparticles (NPs) that were fully characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and dynamic light scattering (DLS). Paclitaxel (PTX) was employed as a model anticancer drug loaded into the NPs (PTX-NPs) using the same method. The sensitivity of AO12CB[6] NPs to a high concentration of GSH upon UVA irradiation was investigated in the absence and presence of 10 mM GSH, respectively. Subsequently, the drug release profile of PTX-NPs in the absence and presence of 1 and 10 mM GSH (respectively representing the GSH conditions inside non-cancerous and cancer cells) under UVA irradiation was evaluated using HPLC. Furthermore, the cytotoxicity profile of the NPs were adequately examined in vitro against a few cell lines, and the selective therapeutic efficacy of PTX-NPs against cancer cells was examined with non-can cells for comparison, via MTT and apoptosis assays. Results: The NPs exhibited uniform and stable spherical morphology in an aqueous solution, high drug loading efficiency and content, effective cellular uptake and selective drug release in cancer cells (due to the presence of GSH) upon light irradiation, leading to improved therapeutic efficacy towards cancer cells and safety on noncancerous cells. Discussion: This study provides the first, facile CB[6] derivative based nanomedicine platform for efficient stimuli-responsive release of hydrophobic drugs in cancer cells in a selective manner. This new discovery will further strengthen the development of other CB[6] derivatives based nanoparticles for biomedical applications. |
| Keyword | Dual stimuli-responsive perallyloxycucurbit[6]uril nanoparticles drug delivery |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 44766 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. Dual stimuli-responsive perallyloxycucurbit[6]uril-based nanoparticles for selective drug delivery in cancer cells[C], 2019. |
| APA | Wang, R..(2019). Dual stimuli-responsive perallyloxycucurbit[6]uril-based nanoparticles for selective drug delivery in cancer cells. Sixth International Conference on Multifunctional, Hybrid and Nanomaterials. |
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