| Status | 已發表Published |
| Supramolecular Medicine and Biomaterials based on Macrocyclic Molecules | |
Wang, R.
| |
| 2018-11-16 | |
| Source Publication | 2018 Shanghai Eastern Forum of Science and Technology - Supramolecular Chemistry
 |
| Abstract | Cucurbit[n]urils (CB[n]), an emerging family of macrocyclic molecules, consist of n glycoluril units connected by 2n methylene groups, and they possess not only a hydrophobic internal cavity that can encapsulate various lipophilic guest molecules, but also the two carbonyl-fringed portals that are good cation-receptors. Our research group has been actively investigating CB[n]’s biocompatibility and their complexations with a variety of drug molecules and biomedically important molecules during the past a couple of years,1 from both organic chemistry and pharmaceutical sciences perspectives. For instance, we are the first to investigate CB[n]’s potential as a taste-concealing agent and as a reversal agent for toxic reagents or drugs.2,3,4 Very recently, we have incorporated CB[n]s and their derivatives into a variety of functional nanobiomaterials for controlled payload release.5,6,7 We are also attempting to extend relevant studies into other macrocyclic molecules such as cyclodextrins, calixarenes and pillararenes to fully leverage the unique physical/chemical properties from each family of these host molecules. |
| Keyword | supramolecular chemistry biomaterials |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 42980 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Wang, R.. Supramolecular Medicine and Biomaterials based on Macrocyclic Molecules[C], 2018. |
| APA | Wang, R..(2018). Supramolecular Medicine and Biomaterials based on Macrocyclic Molecules. 2018 Shanghai Eastern Forum of Science and Technology - Supramolecular Chemistry. |
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