Glutathione-Responsive Polymeric Nanomedicine with Modularly Tailorable Surface

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Glutathione-Responsive Polymeric Nanomedicine with Modularly Tailorable Surface
	Sun, C; Wang, R.
	2018-09-14
Source Publication	5th Symposium on Innovative Polymers for Controlled Delivery
Abstract	Surface functionalization of nanoparticles (NPs) is of pivotal importance in nanomedicine. However, traditional strategies often require covalent conjugation that involves laborious design and synthesis. Herein, Cucurbit[7]uril (CB[7])-decorated disulfide-PLA NPs were developed and exploited for the first time as a stimuli-responsive and versatile drug delivery platform with a noncovalently tailorable surface. CB[7] on the surface of NPs, acting as a “Lego” base block, allowed facile, modular surface modification with a variety of functional moieties or tags that are linked with amantadine (a complementary “Lego” piece to the base block), including amantadine conjugated folate (for targeted delivery), polyethylene glycol (for reducing immunogenicity) and fluorescein isothiocyanate (as a dye label). In addition, surface CB[7] also provided an opportunity for encapsulation of a secondary drug, such as oxaplatin, into the cavity of the base block CB[7], in addition to a primary drug (e.g. paclitaxel) loaded into PLA NPs, for a synergistic chemotherapy. The modular functionalization of the NPs with each of these ligands was verified chemically as well as with cellular studies for stimuli-responsive drug delivery selectively in cancer cells. This proof of concept not only provides the first versatile PLA nanomedicine platform with “Lego” surface for modular functionalization and improved drug delivery in cancer cells, but also offers new insights to the design and development of novel nanomedicine with a modular surface.
Keyword	Stimuli-responsive nanomedicine tailorable
Language	英語English
The Source to Article	PB_Publication
PUB ID	42341
Document Type	Conference paper
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Wang, R.
Recommended Citation GB/T 7714	Sun, C,Wang, R.. Glutathione-Responsive Polymeric Nanomedicine with Modularly Tailorable Surface[C], 2018.
APA	Sun, C., & Wang, R. (2018). Glutathione-Responsive Polymeric Nanomedicine with Modularly Tailorable Surface. 5th Symposium on Innovative Polymers for Controlled Delivery.

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