| Status | 已發表Published |
| Polymeric Nanomedicine with Cucurbit[7]uril on the Surface Allowing Modular Functionalization for Smart Drug Delivery | |
Wang, R. 
| |
| 2018-08-01 | |
| Source Publication | The 19th Macrocyclic Chemistry and the 11th Supramolecular Chemistry National Symposium
 |
| Abstract | Surface functionalization of nanoparticles (NPs) is of pivotal importance in nanomedicine. However, current strategies often require covalent conjugation that involves laborious design and synthesis. Herein, cucurbit[7]uril (CB[7])-decorated PLA/PLGA NPs are developed and exploited for the first time as a novel, biocompatible and versatile drug delivery platform with a noncovalently tailorable surface (Scheme 1). CB[7] on the surface of NPs, acting as an anchoring point, allowed facile, modular surface modification with a variety of functional moieties or tags that are linked with amantadine (a complementary binding moiety to CB[7]), including amantadine conjugated folate, polyethylene glycol and fluorescein isothiocyanate. In addition, surface CB[7] also provided an opportunity for encapsulation of a secondary drug, such as oxaplatin, into the cavity of the base block CB[7], in addition to a primary drug (e.g. paclitaxel) loaded into PLA/PLGA NPs, for a possible synergistic chemotherapy. This proof of concept not only provides the first versatile PLA/PLGA nanomedicine platform with “Lego” surface for modular functionalization and improved drug delivery, but also offers new insights to the design and development of novel nanomedicine with a modular surface. |
| Keyword | Polymeric nanomedicine Cucurbit[7]uril Drug delivery |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 38618 |
| Document Type | Conference paper |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Wang, R. |
| Recommended Citation GB/T 7714 | Wang, R.. Polymeric Nanomedicine with Cucurbit[7]uril on the Surface Allowing Modular Functionalization for Smart Drug Delivery[C], 2018. |
| APA | Wang, R..(2018). Polymeric Nanomedicine with Cucurbit[7]uril on the Surface Allowing Modular Functionalization for Smart Drug Delivery. The 19th Macrocyclic Chemistry and the 11th Supramolecular Chemistry National Symposium. |
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