This study examines employees’ sense of power as a predictor of job crafting. Building on situated focus theory of power, we hypothesize that a personal sense of power enables employees to become more flexible, which in turn activates their job-crafting behavior. We further propose that perceived organizational support (POS) moderates this indirect relationship. Data were collected from 407 Chinese working adults via a three-phase online survey. The empirical results supported our proposed model. The findings suggest that to encourage job-crafting behavior, managers and organizations should seek to enhance their employees’ sense of power, provide training to cultivate flexibility, and ensure that their employees have POS.