| Status | 已發表Published |
| Interpolated Average CT for Reducing Cardiac PET/CT Artifacts | |
Mok, S. P.  ; Ho, Y. T.  ; Sun, T
| |
| 2013-10-01 | |
| Source Publication | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
 |
| Pages | S186-S186 |
| Abstract | Aim: Previously we evaluated the interpolated averaged CT (IACT) method for improved attenuation correction (AC) in noise-free cardiac PET/CT simulations. This study aims to demonstrate its effectiveness in realistic noisy simulations and clinical data. Materials and methods: We first simulated realistic noisy 18F-FDG distribution based on the clinical count level using the digital 4D Extended Cardiac Torso phantom (XCAT) with respiratory motion amplitudes of 2 cm, 3 cm and 4 cm. The average activity and attenuation maps represented static PET and cine average CT (CACT) respectively, while the end-inspiration and end-expiration phases of the attenuation maps represented 2 helical CTs (HCT-1 and HCT-8). We used B-spline registration method combined with an empirical sinusoidal function to generate interpolated phases between 2 extreme phases. IACT was obtained by averaging the original and interpolated phases. The noisy sinograms with attenuation modeling were generated and reconstructed with CACT, HCTs and IACT by STIR (Software for Tomographic Image Reconstruction). Later we recruited 4 patients who had their scheduled whole body PET/CT scans under local ethics approval. They were scanned 1 hr post 315~428 MBq 18F-FDG injection. The PET sinograms were reconstructed with AC using: (i) standard HCT (120 kV, smart mA (30-150 mA), 0.984:1 pitch); (ii) IACT from 2 end-inspiration and end-expiration breath-hold HCTs (120 kV, 10 mA, 0.984:1 pitch) aided by an active breathing controller; (iii) CACT (120 kV, 10 mA, 5.9 s duration). Bull’s eye plots were generated from the short-axis images and the corresponding circumferential profiles were analyzed. Effective dose of different CT protocols were also estimated. Results: The bull’s eye plots of PET-IACT were more similar to PET-CACT from visual inspection in both simulations and clinical data. Artifacts were observed in various locations including anterior, anterolateral, apical lateral, anteroseptal and inferior segments in PET-HCT. The circumferential profiles from different apex-to-base distances consistently showed that PET-IACT closely approached to PET-CACT while PET-HCT showed substantial variations. The mean effective doses were 0.38 mSv, 2.26 mSv and 2.01 mSv for IACT, HCT and CACT respectively. The IACT reduced ~83% effective dose as compared to HCT. Conclusion: The IACT based AC reduced respiratory artifacts in cardiac PET. It is a promising low dose alternate of CACT to improve cardiac PET/CT imaging. |
| Keyword | PET/CT Attenuation Correction Artifacts |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 13075 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING |
| Corresponding Author | Mok, S. P. |
| Recommended Citation GB/T 7714 | Mok, S. P.,Ho, Y. T. ,Sun, T. Interpolated Average CT for Reducing Cardiac PET/CT Artifacts[C], 2013, S186-S186. |
| APA | Mok, S. P.., Ho, Y. T. ., & Sun, T (2013). Interpolated Average CT for Reducing Cardiac PET/CT Artifacts. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, S186-S186. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment