Background and Aims Correlates and risk factors for gambling disorder among vulnerable or transient populations such as transnational migrant workers are largely unknown. The current study examined the prevalence and sociodemographic and spatial correlates of gambling disorder among Filipino domestic workers in Macao (SAR), People’s Republic of China. Design A survey-based, respondent-driven sampling study administered from November 2016 to August 2017. Setting Macao (SAR), which encompasses 38 casinos within its 30.4 km2 area. Participants A representative sample of N=1194 Filipino domestic workers in Macao. Measurements Symptoms of gambling disorder based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Correlates evaluated included sociodemographic information, proximity to gambling venues, perceived social support, and symptoms of depression and anxiety. Findings: Prevalence of gambling disorder was 5.1%. Multivariable regression analyses indicated that the likelihood of gambling participation (i.e., ever gambling) was associated with current indebtedness (RR=1.59, 95% CI = 1.10-2.29, p=0.013), worse self-reported health (RR=1.33, 95% CI = 1.06-1.68, p=0.014), and increased anxiety severity (RR=1.22, 95% CI = 1.004-1.47, p=0.045). Increased symptoms of gambling disorder were independently associated with lower perceived social support (RR=0.919, 95% CI = 0.87-0.97, p=0.004), increased numbers of dependents upon monthly remittances (RR=1.10, 95% CI = 1.05-1.15, p=0.000), increased depression severity (RR=1.17, 95% CI = 1.09-1.27, p=0.000), living apart from an employer (RR=1.61, 95% CI = 1.09-2.37, p=0.017), and proximity to the nearest Mocha Club gaming venues (RR=1.05, 95% CI = 1.02-1.08, p=0.001). The association between proximity to casinos and increased symptoms of gambling disorder was significant only for domestic workers living apart from their employers (RR=1.08, 95% CI = 1.02-1.14, p=0.008). Conclusions: Increased spatial proximity to gambling venues as well as greater financial and psychosocial burdens appear to be associated with gambling disorder among domestic workers in Macao.