This brief describes a fully integrated 10-V pulse driver. It comprises a four-stage switched-capacitor voltage multiplier (SCVM) and a dedicated high-voltage output driver (HVOD) with multiband pulse-frequency modulation (MPFM) to generate efficiently 10 V regulated output pulses. Specifically, an analog/digital hybrid-controlled current-starved ring oscillator (HCRO) modulates the switching frequencies at distinct bands to regulate the high-voltage (HV) supply for the HVOD, while enabling fast output transitions with an improved driving efficiency. Prototyped in 65-nm bulk CMOS, the driver demonstrates 10-V pulse generations over a 0.1-to-1-MHz range for a 15 pF//50 k Omega load. With the proposed MPFM, this work measures an overall driving efficiency of up to 19.9%, corresponding to a similar to 1.6x improvement over prior arts. The measured output rise time of 119 ns is also similar to 25% faster when compared with using the conventional pulse-frequency modulation (PFM) scheme.