Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease
	Tan, Y.; Liu, Y.; Liu, Y.; Ma, R.; Luo, J.; Hong, H.; Chen, X.; Wang, S.; Liu, C.; Zhang, Y.; Chen, T.
	2021-11-19
Source Publication	Research
ISSN	2639-5274
Pages	9812523-9812523
Abstract	Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease (PD), presenting within the form of excessive reactive oxygen species (ROS) generation as well as energy metabolism. Overcoming this dysfunction within brain tissues is an effective approach to treat PD, while unluckily, the blood-brain barrier (BBB) substantially impedes intracerebral drug delivery. In an effort to improve the delivery of efficacious therapeutic drugs to the brain, a drug delivery platform hydrogel (MAG-NCs@Gel) was designed by complexing magnolol (MAG)-nanocrystals (MAG-NCs) into the noninvasive thermosensitive poly(N-isopropylacrylamide) (PNIPAM) with self-gelation. The as-prepared MAG-NCs@Gel exhibited obvious improvements in drug solubility, the duration of residence with the nasal cavity, and the efficiency of brain targeting, respectively. Above all, continuous intranasal MAG-NCs@Gel delivery enabled MAG to cross the BBB and enter dopaminergic neurons, thereby effectively alleviating the symptoms of MPTP-induced PD. Taking advantage of the lower critical solution temperature (LCST) behavior of this delivery platform increases its viscoelasticity in nasal cavity, thus improving the efficiency of MAG-NCs transit across the BBB. As such, MAG-NCs@Gel represented an effective delivery platform capable of normalizing ROS and adenosine triphosphate (ATP) in the mitochondria of dopaminergic neurons, consequently reversing the mitochondrial dysfunction and enhancing the behavioral skills of PD mice without adversely affecting normal tissues.
Keyword	N/A
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	62357
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Zhang, Y.; Chen, T.
Recommended Citation GB/T 7714	Tan, Y.,Liu, Y.,Liu, Y.,et al. Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease[J]. Research, 2021, 9812523-9812523.
APA	Tan, Y.., Liu, Y.., Liu, Y.., Ma, R.., Luo, J.., Hong, H.., Chen, X.., Wang, S.., Liu, C.., Zhang, Y.., & Chen, T. (2021). Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease. Research, 9812523-9812523.
MLA	Tan, Y.,et al."Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease".Research (2021):9812523-9812523.

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