MnSOD mediates shear stress-promoted tumor cell migration and adhesion

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	MnSOD mediates shear stress-promoted tumor cell migration and adhesion
	Ma, S; Fu, A; Lim, S; Chiew, GGY; Luo, KQ
	2018-09-05
Source Publication	Free Radical Biology and Medicine
ISSN	0891-5849
Pages	46-58
Abstract	Circulation of cancer cells in blood stream is a vital step for distant metastasis, during which cancer cells are exposed to hemodynamic shear stress (SS). The actions of SS on tumor cells are complicated and not fully understood. We previously reported that fluidic SS was able to promote migration of breast cancer cells through elevating cellular ROS level. In this study, we further investigated the mechanisms regulating SS-promoted cell migration and identified the role of MnSOD in the related pathway. We found that SS could enhance tumor cell adhesion to extracellular matrix and endothelial monolayer, and MnSOD also regulated this process. Briefly, SS stimulates the generation of mitochondrial superoxide in tumor cells. MnSOD converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion. Combining our previous and present studies, we present experimental evidence on the pro-metastatic effects of hemodynamic SS and reveal the underlying mechanism. Our findings provide new insights into the nature of cancer metastasis and the understanding of tumor cell responses to external stresses, and have valuable implications on cancer therapy development.
Keyword	Shear stress Tumor cell adhesion Tumor cell migration Reactive oxygen species MnSOD FAK
Language	英語English
The Source to Article	PB_Publication
PUB ID	37719
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Luo, KQ
Recommended Citation GB/T 7714	Ma, S,Fu, A,Lim, S,et al. MnSOD mediates shear stress-promoted tumor cell migration and adhesion[J]. Free Radical Biology and Medicine, 2018, 46-58.
APA	Ma, S., Fu, A., Lim, S., Chiew, GGY., & Luo, KQ (2018). MnSOD mediates shear stress-promoted tumor cell migration and adhesion. Free Radical Biology and Medicine, 46-58.
MLA	Ma, S,et al."MnSOD mediates shear stress-promoted tumor cell migration and adhesion".Free Radical Biology and Medicine (2018):46-58.

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