Residential College | false |
Status | 已發表Published |
Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation | |
Zhang, A.1; Yao, C.1; Hang, T.1; Chen, M.4; He, G.1,5; Chen, H.1; Xie, X.1,2,3 | |
2022-01-31 | |
Source Publication | ACS Applied Nano Materials |
ISSN | 2574-0970 |
Volume | 5Issue:2Pages:2057-2067 |
Abstract | Nano-electroporation technology allows external biomolecules to cross the cell membrane and enter cells. Nanostraws (NSs) with hollow channels are promising nanostructures to provide nano-electroporation for intracellular delivery, yet the preparation processes of NSs usually require intricated nanofabrication instruments and possess high requirements for operations. Here, a straightforward spin-coating processing technique was developed to prepare oxide NS arrays without relying on delicate instruments, which could be further integrated with microfluidic devices for effective cell nano-electroporation. The fabrication procedures of these NSs were simpler than the reported method relying on atomic layer deposition and Cl2 reactive ion etching. By this spin-coating method, SiO2 and TiO2 NSs were successfully prepared with controllable NS diameters and spacing. SiO2 and TiO2 NSs were further integrated with a microfluidic system to build a nano-electroporation system, which realized efficient intracellular drug delivery of cell membrane-impermeable molecules into both HeLa cells and MCF-7 cells. This strategy provides a unique solution for batch fabrication of NSs with a low-cost process, which could serve as the essential module of a nano-electroporation platform for various biomedical studies. |
Keyword | Spin-coating Nanostraw Array Oxide Nanostraw Nano-electroporation Intracellular Delivery |
DOI | 10.1021/acsanm.1c03783 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Science & Technology - Other Topics ; Materials Science |
WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS ID | WOS:000757861600001 |
The Source to Article | PB_Publication |
Scopus ID | 2-s2.0-85124015770 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Corresponding Author | Chen, H.; Xie, X. |
Affiliation | 1.State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, China 2.Key Laboratory of Display Material and Technology, School of Electronics and Information. Technology, Sun Yat-sen University, Guangzhou, 510006, China 3.Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macao 4.Key Lab. of Molec. Target and Clin. Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China 5.First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Zhang, A.,Yao, C.,Hang, T.,et al. Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation[J]. ACS Applied Nano Materials, 2022, 5(2), 2057-2067. |
APA | Zhang, A.., Yao, C.., Hang, T.., Chen, M.., He, G.., Chen, H.., & Xie, X. (2022). Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation. ACS Applied Nano Materials, 5(2), 2057-2067. |
MLA | Zhang, A.,et al."Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation".ACS Applied Nano Materials 5.2(2022):2057-2067. |
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