UM  > Institute of Chinese Medical Sciences
Residential Collegefalse
Status已發表Published
Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation
Zhang, A.1; Yao, C.1; Hang, T.1; Chen, M.4; He, G.1,5; Chen, H.1; Xie, X.1,2,3
2022-01-31
Source PublicationACS Applied Nano Materials
ISSN2574-0970
Volume5Issue:2Pages:2057-2067
Abstract

Nano-electroporation technology allows external biomolecules to cross the cell membrane and enter cells. Nanostraws (NSs) with hollow channels are promising nanostructures to provide nano-electroporation for intracellular delivery, yet the preparation processes of NSs usually require intricated nanofabrication instruments and possess high requirements for operations. Here, a straightforward spin-coating processing technique was developed to prepare oxide NS arrays without relying on delicate instruments, which could be further integrated with microfluidic devices for effective cell nano-electroporation. The fabrication procedures of these NSs were simpler than the reported method relying on atomic layer deposition and Cl2 reactive ion etching. By this spin-coating method, SiO2 and TiO2 NSs were successfully prepared with controllable NS diameters and spacing. SiO2 and TiO2 NSs were further integrated with a microfluidic system to build a nano-electroporation system, which realized efficient intracellular drug delivery of cell membrane-impermeable molecules into both HeLa cells and MCF-7 cells. This strategy provides a unique solution for batch fabrication of NSs with a low-cost process, which could serve as the essential module of a nano-electroporation platform for various biomedical studies.

KeywordSpin-coating Nanostraw Array Oxide Nanostraw Nano-electroporation Intracellular Delivery
DOI10.1021/acsanm.1c03783
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000757861600001
The Source to ArticlePB_Publication
Scopus ID2-s2.0-85124015770
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChen, H.; Xie, X.
Affiliation1.State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, Guangzhou, Guangdong Province, 510006, China
2.Key Laboratory of Display Material and Technology, School of Electronics and Information. Technology, Sun Yat-sen University, Guangzhou, 510006, China
3.Institute of Chinese Medical Sciences, University of Macau, Taipa, 999078, Macao
4.Key Lab. of Molec. Target and Clin. Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China
5.First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zhang, A.,Yao, C.,Hang, T.,et al. Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation[J]. ACS Applied Nano Materials, 2022, 5(2), 2057-2067.
APA Zhang, A.., Yao, C.., Hang, T.., Chen, M.., He, G.., Chen, H.., & Xie, X. (2022). Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation. ACS Applied Nano Materials, 5(2), 2057-2067.
MLA Zhang, A.,et al."Spin-coating-based fabrication of nanostraws array for cellular nano-electroporation".ACS Applied Nano Materials 5.2(2022):2057-2067.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, A.]'s Articles
[Yao, C.]'s Articles
[Hang, T.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, A.]'s Articles
[Yao, C.]'s Articles
[Hang, T.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, A.]'s Articles
[Yao, C.]'s Articles
[Hang, T.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.