| Status | 已發表Published |
| A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy | |
Wu, Y.; Li, J.; Zhong, X.; Shi, J.; Cheng, Y.; He, C.; Li, J.; Zou, L.; Fu, C.; Chen, M.; Zhang, J. ; Gao, H.
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| 2022 | |
| Source Publication | Asian Journal of Pharmaceutical Sciences
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| ISSN | 1818-0876 |
| Pages | N-N |
| Abstract | The combination of Ce6, an acknowledged photosensitizer, and TPL, a natural anticancer agent, has been demonstrated as a useful strategy to reinforce the tumor growth suppression, as well as decrease the systemic side effects compared with their monotherapy. However, in view of the optimal chemo-photodynamic combination efficiency, there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL, and stimuli-responsively burst release drugs in tumor site. Herein, we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem, mediated by the host–guest complexing between β-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG, showing the shell–core structural micelles with the tight β-CD layer coating. Both Ce6 and TPL were facilely co-loaded into the spherical supramolecular NPs (TPL+Ce6/NPs) by one-step nanoprecipitation method, with an ideal particle size (156.0 nm), acid pH-responsive drug release profile, and enhanced cellular internalization capacity. In view of the combination benefit of photodynamic therapy and chemotherapy, as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs, TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation, boost ROS level, lower MMP, and promote cellular apoptosis in vitro. Particularly, fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area, with higher intensity than that of free Ce6. As expected, upon 650-nm laser irradiation, TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearing mice and B16 tumor-bearing mice. More importantly, lower systemic toxicity was found in the tumor-bearing mice treated with TPL+Ce6/NPs. Overall, the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment. |
| Keyword | Triptolide Chemo-photodynamic pH-sensitive supramolecular nanosystem Co-delivery |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 63093 |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Zhang, J.; Gao, H. |
| Recommended Citation GB/T 7714 | Wu, Y.,Li, J.,Zhong, X.,et al. A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy[J]. Asian Journal of Pharmaceutical Sciences, 2022, N-N. |
| APA | Wu, Y.., Li, J.., Zhong, X.., Shi, J.., Cheng, Y.., He, C.., Li, J.., Zou, L.., Fu, C.., Chen, M.., Zhang, J.., & Gao, H. (2022). A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy. Asian Journal of Pharmaceutical Sciences, N-N. |
| MLA | Wu, Y.,et al."A pH-sensitive supramolecular nanosystem with chlorin e6 and triptolide co-delivery for chemo-photodynamic combination therapy".Asian Journal of Pharmaceutical Sciences (2022):N-N. |
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