Imaging Genomics supports Dual System for Utility of Risks over Gains and Losses

UM > Faculty of Business Administration > DEPARTMENT OF INTEGRATED RESORT AND TOURISM MANAGEMENT

Status	已發表Published
	Imaging Genomics supports Dual System for Utility of Risks over Gains and Losses
	Zhong, SF; Chark, C. H.; Ebstein, RP; Chew, SH
	2012-01-02
Source Publication	NeuroImage
ISSN	1053-8119
Pages	540-546
Abstract	One tenet of behavioral economics is the asymmetry in how decision makers evaluate risks involving gains versus risks involving losses. Correspondingly, an increasingly important question is what neuroanatomical and neurochemical correlates underpin valuation over gains and losses. By employing an imaging genetics strategy, this paper aims at identifying the specific neurotransmitter pathways underlying these decision making processes. We find enhanced striatal activation responding to increases in the magnitude of utility for risks over gains and to increases in the magnitude of disutility for risks over losses, while increased amygdala activation correlates only with the disutility for risks over losses. Stratifying brain activation by genotype, we find that a well-characterized polymorphism in the dopamine transporter (DAT1) contributes to individual differences in striatal response for gain-oriented risks, whereas a polymorphism in the serotonin transporter (STin2) partially accounts for individual differences in amygdala responses for loss-oriented risks. Together, our results suggest the role of the amygdala and corresponding serotonergic pathway in evaluating losses. This further corroborates the hypothesis of serotonin being linked to dopamine in an “opponent partnership”
Keyword	Striatum Amygdala Dopamine Serotonin Decision making under risk Imaging genetics
Language	英語English
The Source to Article	PB_Publication
PUB ID	21452
Document Type	Journal article
Collection	DEPARTMENT OF INTEGRATED RESORT AND TOURISM MANAGEMENT
Corresponding Author	Ebstein, RP; Chew, SH
Recommended Citation GB/T 7714	Zhong, SF,Chark, C. H.,Ebstein, RP,et al. Imaging Genomics supports Dual System for Utility of Risks over Gains and Losses[J]. NeuroImage, 2012, 540-546.
APA	Zhong, SF., Chark, C. H.., Ebstein, RP., & Chew, SH (2012). Imaging Genomics supports Dual System for Utility of Risks over Gains and Losses. NeuroImage, 540-546.
MLA	Zhong, SF,et al."Imaging Genomics supports Dual System for Utility of Risks over Gains and Losses".NeuroImage (2012):540-546.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh