Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers
	Chang, C.L.; Bodogai, M.; Moritoh, K.; Chen, X.; Wersto, R.; Sen, R.; Young, H.A.; Croft, M.; Ferrucci, L.; Biragyn, A.
	2016-04-15
Source Publication	Journal of Immunology
ISSN	0022-1767
Pages	3385-3397
Abstract	B cell dysregulation in aging is thought to mostly occur in conventional B2 cells without affecting innate B1 cells. Elderly humans and mice also accumulate 4-1BBL+ MHC class-IHi CD86Hi B cells of unknown origin. In this article, we report that these cells, termed 4BL cells, are activated murine and possibly human B1a cells. The activation is mediated by aging human monocytes and murine peritoneal macrophages. They induce expression and activation of 4-1BBL and IFN-γR1 on B1a cells to subsequently upregulate membrane TNF-α and CD86. As a result, activated B1a/4BL cells induce expression of granzyme B in CD8+ T cells by targeting TNFR2 via membrane TNF-α and providing costimulation with CD86. Thus, for the first time, to our knowledge, these results indicate that aging affects the function of B1a cells. Upon aging, these cells lose their tumor-supporting activity and become inducers of potentially antitumor and autoimmune CD8+ T cells.
Keyword	CD8 T cells B cells Aging TNFR2
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	22603
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Biragyn, A.
Recommended Citation GB/T 7714	Chang, C.L.,Bodogai, M.,Moritoh, K.,et al. Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers[J]. Journal of Immunology, 2016, 3385-3397.
APA	Chang, C.L.., Bodogai, M.., Moritoh, K.., Chen, X.., Wersto, R.., Sen, R.., Young, H.A.., Croft, M.., Ferrucci, L.., & Biragyn, A. (2016). Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers. Journal of Immunology, 3385-3397.
MLA	Chang, C.L.,et al."Aging Converts Innate B1a Cells into Potent CD8+ T Cell Inducers".Journal of Immunology (2016):3385-3397.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh