In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.
	Zhou, Q.; Hu, Y.; Howard, O.; Oppenheim, J.; Chen, X.
	2014
Source Publication	Cytokine
ISSN	1043-4666
Pages	56-64
Abstract	CD4(+) T cells stimulate immune responses through distinct patterns of cytokine produced by Th1, Th2 or Th17 cells, or inhibit immune responses through Foxp3-expressing regulatory T cells (Tregs). Paradoxically, effector T cells were recently shown to activate Tregs, however, it remains unclear which Th subset is responsible for this effect. In this study, we found that Th17 cells expressed the highest levels of TNF among in vitro generated Th subsets, and most potently promoted expansion and stabilized Foxp3 expression by Tregs when co-transferred into Rag1(-/-) mice. Both TNF and IL-2 produced by Th17 cells contributed to this effect. The stimulatory effect of Th17 cells on Tregs was largely abolished when co-transferred with TNFR2-deficient Tregs. Furthermore, Tregs deficient in TNFR2 also supported a much lower production of IL-17A and TNF expression by co-transferred Th17 cells. Thus, our data indicate that the TNF-TNFR2 pathway plays a crucial role in the reciprocal stimulatory effect of Th17 cells and Tregs. This bidirectional interaction should be taken into account when designing therapy targeting Th17 cells, Tregs, TNF and TNFR2.
Keyword	FoxP3 IL-2 KI KO Regulatory T cell TNF TNFR2 TNFR2 Fc fusion protein TNFR2-Fc Teffs Th17 Tregs effector T cells forkhead box P3 knock in knock out nCD4 naïve CD4 cells regulatory T cells tumor necrosis factor receptor type II
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	22619
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chen, X.
Recommended Citation GB/T 7714	Zhou, Q.,Hu, Y.,Howard, O.,et al. In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.[J]. Cytokine, 2014, 56-64.
APA	Zhou, Q.., Hu, Y.., Howard, O.., Oppenheim, J.., & Chen, X. (2014). In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.. Cytokine, 56-64.
MLA	Zhou, Q.,et al."In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.".Cytokine (2014):56-64.

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