Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. International Immunopharmacology.

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. International Immunopharmacology.
	Kopf, H.; Rosa, G.; Howard, O.; Chen, X.
	2007-12-15
Source Publication	International Immunopharmacology
ISSN	1567-5769
Pages	1819-1824
Abstract	Reciprocal differentiation of immunosuppressive CD4+CD25+FoxP3+ T regulatory cells (Tregs) and proinflammatory IL-17-producing cells (Th17) from naïve CD4 cells is contingent upon the cytokine environment. Using MACS-purified CD4 cells, we found that rapamycin and cyclosporine A (CsA) potently inhibited the TGFβ and IL-6-induced generation of IL-17-producing cells. Intriguingly, rapamycin promoted, while CsA markedly inhibited, TGFβ-mediated generation of Tregs. The aforementioned effects of rapamycin and CsA were also observed for Flow-sorted CD4+CD25− T cells, indicating that the effect of these two immunosuppressive agents was based on their action on de novo generation of Tregs and Th17 cells from naïve CD4 cells. Our observation suggests a distinct mode of immunosuppressive action and tolerance induction by rapamycin and CsA. The capacity of rapamycin to generate immunosuppressive Tregs and to suppress differentiation of pathogenic Th17 cells furthers our understanding of the basis for the therapeutic immunosuppressive effects of rapamycin in patients with autoimmune diseases and allo-transplantation reactions.
Keyword	rapamycin CD4+CD25+FoxP3+ T regulatory cells Th17 cells
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34778
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chen, X.
Recommended Citation GB/T 7714	Kopf, H.,Rosa, G.,Howard, O.,et al. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. International Immunopharmacology.[J]. International Immunopharmacology, 2007, 1819-1824.
APA	Kopf, H.., Rosa, G.., Howard, O.., & Chen, X. (2007). Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. International Immunopharmacology.. International Immunopharmacology, 1819-1824.
MLA	Kopf, H.,et al."Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. International Immunopharmacology.".International Immunopharmacology (2007):1819-1824.

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