Effects of IL-7 and Dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on CD4+ cells.

UM > Institute of Chinese Medical Sciences

Status	已發表Published
	Effects of IL-7 and Dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on CD4+ cells.
	Chung, I.Y.; Dong, H.; Zhang, X.; Hassanein, N.; Howard, O.; Oppenheim, J.; Chen, X.
	2004-11-01
Source Publication	Cellular Immunology
ISSN	0008-8749
Pages	57-63
Abstract	Since we have previously shown that dexamethasone (Dex) enhances the proportion of murine Treg cells, we tested the effect of IL-7, a promoter of T cell survival, together with Dex oil human CD4(+)CD25(+) Treg cells in an in vitro setting. The results showed that IL-7 in concert with Dex markedly augmented the generation of CD4(+)CD25(+) T cells. To discern the origin of the induced CD4(+)CD25(+) T cells, MACS-purified CD4(+)CD25(-), and CD4(+)CD25(+) cells were cultured in the presence of Dex and/or IL-7 for 4 days. Although two thirds of CD4(+)CD25(-) T cells became CD4(+)CD25(+) T cells, they had no Suppressive activity. In contrast, the original CD4(+)CD25(+) T cells maintained Suppressive activity after Dex/IL-7 treatment, however, there was not a significant expansion ill their cell number. Dex and IL-7 did not induce additional Treg cells, but additively induced the expression of the activation marker CD25 by CD4(+)CD25(-) T cells. This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases.
Keyword	CD4(+) CD25(+) regulatory T lymphocytes dexamethasone interleukin-7 suppression/anergy
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	34808
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Chung, I.Y.,Dong, H.,Zhang, X.,et al. Effects of IL-7 and Dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on CD4+ cells.[J]. Cellular Immunology, 2004, 57-63.
APA	Chung, I.Y.., Dong, H.., Zhang, X.., Hassanein, N.., Howard, O.., Oppenheim, J.., & Chen, X. (2004). Effects of IL-7 and Dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on CD4+ cells.. Cellular Immunology, 57-63.
MLA	Chung, I.Y.,et al."Effects of IL-7 and Dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on CD4+ cells.".Cellular Immunology (2004):57-63.

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