Identifcation and functional characterization of novel cofactors of androgen receptor (AR) in prostate cancer cells by RIME

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	Identifcation and functional characterization of novel cofactors of androgen receptor (AR) in prostate cancer cells by RIME
	Chen, M; Lingadahali, S; Liu, S; Lam, M; Lei, K; Poon, T; Cheung, E
	2018-06-01
Source Publication	5th Macau Symposium on Biomedical Sciences
Abstract	Prostate cancer remains a leading cause of male cancer related death worldwide. The androgen receptor (AR) signaling plays a key role in the development and progression of prostate cancer, which makes the AR signaling as a primary target for the treatment of prostate cancer. Co-factors recruitment is a crucial regulatory step in AR signaling pathway. An abundance of evidences have strongly implicated a clear link between AR co-factors and the development and progression of prostate cancer. Using a powerful proteomics approach called rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) , we identified a new AR co-factor, TRIM33 (also known as TIFlγ and RFG7) , and demonstrated its essential role in the AR signaling. TRIM33 co-localized with AR in LNCaP cell. Importantly, TRIM33 regulated the transcriptional activity of AR in a target-dependent manner. Beside, we found that TRIM33 was required for cell proliferation. In summary, our study identified TRIM33 as a novel AR co-factor and a potential therapeutic target for prostate cancer.
Keyword	AR RIME prostate cancer
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	40985
Document Type	Conference paper
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES Faculty of Health Sciences
Corresponding Author	Cheung, E
Recommended Citation GB/T 7714	Chen, M,Lingadahali, S,Liu, S,et al. Identifcation and functional characterization of novel cofactors of androgen receptor (AR) in prostate cancer cells by RIME[C], 2018.
APA	Chen, M., Lingadahali, S., Liu, S., Lam, M., Lei, K., Poon, T., & Cheung, E (2018). Identifcation and functional characterization of novel cofactors of androgen receptor (AR) in prostate cancer cells by RIME. 5th Macau Symposium on Biomedical Sciences.

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