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Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice
Zheng, W.
2021-03-01
Conference Name5th Symposium on Biomedical Sciences for Students, Postdoctoral Fellows and Research Assistants 2021
Source Publication5th Symposium on Biomedical Sciences for Students, Postdoctoral Fellows and Research Assistants 2021
Conference Date2021-03
Conference Place-
Abstract

We established three types of thrombosis models to explore the effects of the static magnetic field (SMF) on thrombosis in rats and mice with three different MF intensities. In the carrageenin-induced thrombosis model in rats, the SMF treatments reduced the black tail length of rats, extracorporeal thrombus, and the mass of wet and dry thrombus, and improved the coagulation index value. However, In FeCl3-induced arterial thrombosis model in rats, the SMF treatment showed some anti-thrombotic effects. More specifically, the SMF treatment affected rodent blood pressure, plasma plasminogen activator inhibitor, tissue-type plasminogen activator, thrombus mass, and thrombus protein content. But In the adrenaline-induced thrombosis model in mice, the SMF treatment had certain effects on the diameter and blood flow velocity of mouse auricle microcirculation in fine veins and arteries. Overall, the highest MF intensities we tested, is 20-150 mT, which showed a trend of anti-thrombotic effect, indicating that the moderate-intensity SMF might serve as a potential treatment for clot-related diseases in the future.

KeywordSmf Clot-related Diseases Rat And Mice
Language英語English
The Source to ArticlePB_Publication
Document TypeConference paper
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Faculty of Health Sciences
Corresponding AuthorZheng, W.
Recommended Citation
GB/T 7714
Zheng, W.. Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice[C], 2021.
APA Zheng, W..(2021). Moderate Intensity Static Magnetic Fields Prevent Thrombus Formation in Rats and Mice. 5th Symposium on Biomedical Sciences for Students, Postdoctoral Fellows and Research Assistants 2021.
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