| Status | 已發表Published |
| Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer’s Disease and protective effect validation of Chlorogenic acid | |
Li, Q.; Zheng, W. 
| |
| 2020-11-01 | |
| Source Publication | The 4th National Basic Research Symposium on the Quality of Traditional Chinese Medicine 2020
 |
| Pages | 27-null |
| Abstract | Objective: This study aims to explore the possible homologous mechanism of seven frequently-used herbs for heat-clearing and detoxification in traditional Chinese medicine (HDTCM) for treating Alzheimer’s disease (AD), which based on network pharmacology. Methods: Herbs that satisfied the criteria of containing chlorogenic acid, relating to AD and aligning with HDTCM, were simultaneously collected to determine whether they have anti-AD effect based on a survey of the literature. Herb-ingredient-target-disease networks were constructed by collecting information from the TCMSP and Gene Cards public data bases. The common targets of the herbs and AD were identified for conducting a Gene Ontology (GO) analyses and a Reactome pathway enrichment analysis. Results: The results showed that PTGS1, IL-6, CASP3, and VEGFA were the predicted key gene targets. The IL-4 and IL-13 signaling pathway, the ESR-mediated signaling pathway, and the extranuclear estrogen signaling pathway were significant pathways associated with the seven herbs. Chlorogenic acid, one of the common component, was tested whether it can affect the expression of SIRT1, the common upstream factors of these targets and pathways. Conclusions: This study revealed that the analogous anti-AD mechanism of the seven herbs of HDTCM may be associated with anti-inflammation, which is a common effect of the chlorogenic acid and quercetin components. Among them, chlorogenic acid can significantly increase the expression of SIRT1 in PC12 cells induced by aluminum maltol, a model of AD in in vitro. |
| Keyword | Network Pharmacology Heat-Clearing and Detoxifying Traditional Chinese Medicine Alzheimer’s Disease Chlorogenic acid |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 55815 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Li, Q.,Zheng, W.. Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer’s Disease and protective effect validation of Chlorogenic acid[C], 2020, 27-null. |
| APA | Li, Q.., & Zheng, W. (2020). Network Pharmacology Study of Heat-Clearing and Detoxifying Traditional Chinese Medicine for Alzheimer’s Disease and protective effect validation of Chlorogenic acid. The 4th National Basic Research Symposium on the Quality of Traditional Chinese Medicine 2020, 27-null. |
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