| Status | 已發表Published |
| Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury | |
Lin, R.; Zheng, W. 
| |
| 2020-11-01 | |
| Source Publication | The 4th National Basic Research Symposium on the Quality of Traditional Chinese Medicine 2020
 |
| Pages | 28-null |
| Abstract | Depression is a prevalent psychiatric disorder and a leading cause of disability worldwide. Despite the amount of available treatments currently being used in the clinic, a substantial proportion of patients is unresponsive to them, urging the need to develop more effective therapeutic approaches. Hederagenin, is a triterpenoid saponin first found in ivy (Hedera helix L.), demonstrates several biological activities, including anti-apoptosis, anti-hyperlipidemic, anti-inflammatory properties, and has been shown to have potential therapeutic roles in depression, however, the role of hederagenin in depression has not been elucidated. Chronic and high dosages of corticosterone treatment are able to stimulate anxiety- and depression-like behavioral changes in behavior, neurochemistry and brain morphology such as the reduction of hippocampal cells. The present study reports that corticosterone-induced damage to PC12 cells can be ameliorated by hederagenin treatment. Specifically, hederagenin prevented the decline of mitochondrial membrane potential, reduced intracellular ROS production and decrease apoptosis induced by corticosterone. Moreover, hederagenin neuroprotective effect is likely to occur via suppression of AKT signaling pathway activation. These findings support that hederagenin may be a potential drug for the prevention and treatment of depression. |
| Keyword | Hederagenin AKT PC12 cells corticosterone injury |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 55816 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Lin, R.,Zheng, W.. Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury[C], 2020, 28-null. |
| APA | Lin, R.., & Zheng, W. (2020). Hederagenin stimulated AKT activation and rescued PC12 cells from corticosterone injury. The 4th National Basic Research Symposium on the Quality of Traditional Chinese Medicine 2020, 28-null. |
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