| Status | 已發表Published |
| Caffeic acid phenethyl ester protects against experimental autoimmune encephalomyelitis through regulating T cell activities | |
Zheng, W.
| |
| 2020-10-09 | |
| Source Publication | Oxidative Medicine and Cellular Longevity, accepted
 |
| ISSN | 1916-9671 |
| Pages | 1-13 |
| Abstract | Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) characterized by progressive demyelination and disabling outcomes. CD4+ T cell is the most critical driving factor of relapsing MS, but little improvement has been noted upon deletion of the whole T cell population. Caffeic acid phenethyl ester (CAPE), one of the main active compounds of propolis, exhibits potent anti-tumour, anti-inflammatory and antioxidant properties by suppressing nuclear factor-κB (NF-κB) transactivation. To investigate the therapeutic potential of CAPE in MS, we studied the effect of CAPE on the cytokine levels, T cells and NF-κB activities and in an experimental MS animal model. The results showed that the cerebrospinal fluid (CSF) from patients with relapsing MS is characterized by increased levels of pro-inflammatory cytokines/chemokines that preferentially skew towards T helper 1 (Th1) cytokines. In vitro studies demonstrated that CAPE not only inhibited T cell proliferation and activation, but also effectively modulated T cell subsets. Under both Th0- and Th1-polarizing conditions, the proportion of CD4+IFN-γ+ cells was down-regulated while the CD4+Foxp3+ cells was increased. Moreover, the nuclear translocation of NF-κB p65 was inhibited by CAPE. In a murine experimental autoimmune encephalomyelitis model, prophylactic treatment with CAPE significantly decreased the disease incidence and severity. Compared to the vehicle group, mice pre-treated with CAPE showed diminished inflammatory cell infiltration, microglia/macrophage activation and demyelination injury. Additionally, CAPE pre-treatment reduced the level of Th1 cells in both spleen and the CNS and increased the regulatory T cell (Treg) of the CNS. In conclusion, our results highlight the potential merit of CAPE in suppressing T cell activity mainly through targeting pathogenic Th1 lineage, which may be beneficial for MS treatment. |
| Keyword | Caffeic acid Multiple sclerosis (MS) autoimmune T cell |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 51670 |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Caffeic acid phenethyl ester protects against experimental autoimmune encephalomyelitis through regulating T cell activities[J]. Oxidative Medicine and Cellular Longevity, accepted, 2020, 1-13. |
| APA | Zheng, W..(2020). Caffeic acid phenethyl ester protects against experimental autoimmune encephalomyelitis through regulating T cell activities. Oxidative Medicine and Cellular Longevity, accepted, 1-13. |
| MLA | Zheng, W.."Caffeic acid phenethyl ester protects against experimental autoimmune encephalomyelitis through regulating T cell activities".Oxidative Medicine and Cellular Longevity, accepted (2020):1-13. |
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