| Residential College | true |
| Status | 已發表Published |
| Autophagy in Aging | |
Zheng, W.
| |
| 2022-01 | |
| Source Publication | Encyclopedia of Gerontology and Population Aging |
| Publisher | Springer Cham |
| Pages | 583–586 |
| Abstract | Autophagy is an essential and highly conserved cellular process that supports cellular renovation and homeostasis by which damaged proteins and organelles are delivered to lysosomes to be removed and degraded (Wong et al. 2019). Depending on the delivery mechanisms of the autophagic cargo to the lysosomes, autophagy can be designated as macroautophagy, chaperone-mediated autophagy, or microautophagy (Wong et al. 2019). In macroautophagy (from here after designated as autophagy), the damaged cargo is engulfed by the autophagosome which then carries it and fuses with the lysosomes. In chaperone-mediated autophagy, the autophagic cargo is transported into the lysosomes by cytosolic chaperone proteins, and in microautophagy the damaged material is directly engulfed by the lysosomes (Wong et al. 2019). The autophagic process responds to a wide variety of cues that include nutritional and metabolic stimulus, providing cells with an adaptive and protective capability to react to stress conditions (Baek and Kim 2017). Aging organisms have been shown to exhibit a gradual decline of autophagy that correlates with an increased accumulation of cellular damage that contributes to the aging phenotype and to the development/progression of several age-related pathologies, such as neurodegenerative diseases and cancer (see “Aging Mechanisms” and “Aging Pathology”) (Cuervo 2008; Barbosa et al. 2019; Loeffler 2019). The progressive loss of proteostasis with aging (see “Cellular Proteostasis in Aging”) constrains the cell’s ability to thrive contributing to a progressive loss of function that culminates in the cell’s death. Likewise, autophagy enhancement might delay the aging process contributing to lifespan extension. |
| Other Abstract | Summary:The observed gradual autophagy decline throughout life contributes to the aging phenotype and predisposes individuals to age-associated diseases. A better understanding of the mechanisms underlying aging and longevity may pave the way to develop reliable antiaging strategies in order to extend individuals’ lifespan and delay aging-associated complications. |
| DOI | https://doi.org/10.1007/978-3-030-22009-9 |
| Language | 英語English |
| ISBN | 978-3-030-22009-9 |
| The Source to Article | https://link.springer.com/referenceworkentry/10.1007/978-3-030-22009-9_438 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Book chapter |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Recommended Citation GB/T 7714 | Zheng, W.. Autophagy in Aging[M]. Encyclopedia of Gerontology and Population Aging:Springer Cham, 2022, 583–586. |
| APA | Zheng, W..(2022). Autophagy in Aging. Encyclopedia of Gerontology and Population Aging, 583–586. |
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