| Residential College | true |
| Status | 已發表Published |
| Cell Damage and Transformation in Aging | |
Zheng, W. 
| |
| 2022-01 | |
| Source Publication | Encyclopedia of Gerontology and Population Aging |
| Publisher | Springer Cham |
| Pages | 841–843 |
| Abstract | Aging is accompanied by an accumulation of cellular damage that ultimately leads to tissue decline and death. Over a lifetime, cells are continuously damaged by exogenous (physical, chemical, and biological agents) and endogenous sources (DNA replication errors, spontaneous hydrolytic reactions, and reactive oxygen species (ROS)), thus increasing the risk of acquiring mutations (Hoeijmakers 2009). In spite of the majority of these mutations being harmless and usually corrected by the DNA repair system, some unrepaired DNA damage may accumulate over time resulting in genomic instability (See “Genome Instability”) and leading to cell senescence and apoptosis (Maynard et al. 2015). Genomic instability, a state with a high frequency of mutations, may initiate malignant transformation (Hanahan and Weinberg 2011). |
| Other Abstract | Summary The accumulation of cellular damage with age can lead to malignant transformation. Although several theories have been established to reveal the relationship between aging and cancer, some fundamental questions remain to be answered. A better understanding on the underlying mechanisms of both age-dependent cellular damage and the initiation and progression of malignant transformation may aid the development of novel therapeutic strategies that could lower the risk of developing cancer and allow lifespan extension as much as possible. |
| Keyword | Cell Dacancer Cellular Aging Cellular Senescence Dna Damage Dna Mutation Malignant Transformationmage |
| DOI | https://doi.org/10.1007/978-3-030-22009-9 |
| Language | 英語English |
| ISBN | 978-3-030-22009-9 |
| The Source to Article | https://link.springer.com/referenceworkentry/10.1007/978-3-030-22009-9_434 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Book chapter |
| Collection | Faculty of Health Sciences DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Cell Damage and Transformation in Aging[M]. Encyclopedia of Gerontology and Population Aging:Springer Cham, 2022, 841–843. |
| APA | Zheng, W..(2022). Cell Damage and Transformation in Aging. Encyclopedia of Gerontology and Population Aging, 841–843. |
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