| Status | 已發表Published |
| Artemisinin protected neuronal cells from oxidative insult via the MAPK pathway | |
Zheng, W. 
| |
| 2016-08-24 | |
| Source Publication | 7th Annual Global Pharma Summit
 |
| Abstract | Artemisinin, also known as Qinghaosu (Chinese: 青蒿素), isolated from artemisia annua , is a drug that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. It is clinical safe, potent and effective in human. At present study, we found that artemisinin promoted the survial of various cell typres such as PC12 cells and primary cortical cultured neurons from oxidative insults. For example, pretreatment of PC12 cells with artemisinin significantly suppressed SNP/H2O2-induced cell death by decreasing the production of intracellular reactive oxygen species (ROS), preventing the decline of mitochondrial membrane potential, restoring abnormal changes in nuclear morphology and reducing LDH and caspase 3/7 activities. Western blotting analysis showed that artemisinin was able to stimulate the phosphorylation/activation of extracellular regulated protein kinases (ERK) kinase and CREB while had no effect on the Akt pathway. In addition, ERK signaling pathway inhibitor PD98059 blocked the protective effect of artemisinin whereas the PI3K inhibitor LY294002 had no effect. Taken together, these results suggest that artemisinin as a potential neuroprotectant is able to suppress varous oxdative stress induced neuronal cell death via the activation of ERK signaling. Our results offer support for the potential development of Artemisinin to prevent neuronal degenerative disorders. Supported by NFSC (31371088), FDCT 021/2015/A1, SRG2015-00004 and MYRG2016-00052 from University of Macau. |
| Keyword | Artemisinin/MAPK pathway |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 27022 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Artemisinin protected neuronal cells from oxidative insult via the MAPK pathway[C], 2016. |
| APA | Zheng, W..(2016). Artemisinin protected neuronal cells from oxidative insult via the MAPK pathway. 7th Annual Global Pharma Summit. |
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