| Status | 已發表Published |
| Overexpression FoxO3a in Retina Reversed Eye Electrical Dysfunction in FoXO Transgenic Mice from Light Injury | |
Zheng, W. 
| |
| 2016-04-25 | |
| Source Publication | BIT 6th Annual Word Congress of Molecular & Cell Biology-2016
 |
| Abstract | FoxO3a, a member of the Fork head family transcriptional factors, plays an important role in diverse physiologic processes including metabolisms, longevity, oxidase stress and opoptosis. However, the role of FoxO3a on retinal photic injury is unknown. In present study, we investigate the effect of FoxO3a on the retina functions and neuronal survival using transgenicanimal overexpression FoxO family members. Our results showed that bright light exposure increased the expression of the apoptotic protein Bax while decreasing the expression of Bcl-2 in retina ganglia cells(RGC), causing dysfunction of retina shown by flash electroretinagram and flash visual evoked potential recordings. Overexpressing FoxO3a in retina increased the expression of Bcl-2, but decreased the expression of BAX and reversed eye electrical dysfunction in mice from light exposure. These results indicate that FoxO3a protected retina from light-induced retinopathy by modulation of expression of apoptotic protein Bcl/Bax in rat eye. Acknowledgement: Partly supported by the organizers of the conference. |
| Keyword | FoxO3a longevity neuronal survival Bax Bcl-2 |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 19184 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Overexpression FoxO3a in Retina Reversed Eye Electrical Dysfunction in FoXO Transgenic Mice from Light Injury[C], 2016. |
| APA | Zheng, W..(2016). Overexpression FoxO3a in Retina Reversed Eye Electrical Dysfunction in FoXO Transgenic Mice from Light Injury. BIT 6th Annual Word Congress of Molecular & Cell Biology-2016. |
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